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NCB-0846
CAS No. : 1792999-26-8
MCE 国际站：NCB-0846
产品活性：NCB-0846是具有口服活性的TNIK抑制剂，IC50值为21?nM。
研究领域：Stem Cell/Wnt | MAPK/ERK Pathway
In Vitro: NCB-0846 has anti-Wnt activity. NCB-0846 binds to TNIK in an inactive conformation, and this binding mode seems to be essential for Wnt inhibition. NCB-0846 shows inhibitory activity against TNIK with an IC50 of 21 nM. NCB-0846 also inhibits FLT3, JAK3, PDGFRα, TRKA, CDK2/CycA2, and HGK. NCB-0846 induces faster migration of TCF4 phosphorylated by TNIK within a concentration range of 0.1-0.3 μM and completely inhibits the phosphorylation of TCF4 at a concentration of 3 μM. NCB-0846 inhibits HCT116 cell growth and shows much higher (-20-fold) inhibitory activity against colony formation by the same cells in soft agar.
In Vivo: NCB-0846 suppresses the growth of tumors established by inoculating HCT116 cells into immunodeficient mice. The expression of Wnt-target genes (AXIN2, MYC and CCND1) in xenografts is reduced following the administration of NCB-0846. NCB-0846 induces an increase in the sub-G1 cell population. Cleavage of poly (ADP-ribose) polymerase 1 indicates the induction of apoptosis.
相关产品：Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Oxygen Sensing Compound Library | Cytoskeleton Compound Library | Orally Active Compound Library | Neuroprotective Compound Library | Anti-Breast Cancer Compound Library | Anti-Obesity Compound Library | Targeted Diversity Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | Antihypertensive Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Serine/Threonine Kinase Inhibitor Library | Extracellular Vesicles (EVs) Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Anti-Gastric Cancer Compound Library | Anti-Fibrosis Compound Library | Laduviglusib | IWR-1 | IWP-2 | Monensin sodium | MSAB | Wnt-C59 | SKL2001 | Heparan Sulfate | Echinacoside | Wogonin | Adavivint | Pyrvinium pamoate | Salinomycin sodium salt | BML-284 | iCRT3 | Ginkgetin | Foxy-5 TFA | FH535 | GNE-495 | Box5 TFA | Platycodin D | Nigericin | Cardamonin | Triptonide | ETC-159 | DMX-5804 | iCRT 14
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