FITC标记的成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体
产品名称： FITC标记的成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体
英文名称： Anti-FGFR1OP/FITC
产品编号： HZ-5712R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FGFR1OP/FITC Conjugated antibody
FITC标记的成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体
| 英文名称 | Anti-FGFR1OP/FITC |
| 中文名称 | FITC标记的成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体 |
| 别 名 | FGFR1OP; Fibroblast growth factor receptor 1 oncogene partner; FOP; FR1OP_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FGFR1OP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FGFR1 Oncogene Partner is required for anchoring microtubules to the centrosomes. Ubiquitous; highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). There are three named isoforms. Function: Required for anchoring microtubules to the centrosomes. Subunit: Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1. Subcellular Location: Cytoplasm, cytoskeleton, centrosome. Note=Associated with gamma-tubulin. Tissue Specificity: Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas. DISEASE: Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity. Similarity: Belongs to the FGFR1OP family. Contains 1 LisH domain. Database links: Entrez Gene: 11116 Human Entrez Gene: 75296 Mouse Entrez Gene: 365103 Rat Entrez Gene: 683722 Rat Omim: 605392 Human SwissProt: Human SwissProt: O95684 Human SwissProt: Q66JX5 Mouse SwissProt: Q4V7C1 Rat Unigene: 487175 Human Unigene: 227250 Mouse Unigene: 166829 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. FGFR1OP蛋白最初是在引起干细胞骨髓增生病的癌蛋白中作为FGFR1的融合伴侣被发现的，目前研究认为，FGFR1OP蛋白在很多组织细胞中都有不同的存在，尤其是以脑, 心，肝，肌肉，肾，小肠，结肠，肾上腺，前列腺，睾丸和胰腺中高表达 |
FGFR1癌基因伴侣需要将微管锚定到中心体。普遍存在于心脏、肝脏、肌肉、肾脏、肠、结肠、肾上腺、前列腺、睾丸和胰腺中。涉及FGFR1OP的染色体畸变可能是干细胞骨髓增生性疾病（MPD）的一个原因。有三个命名的异构体。