RAPGEF5/Repac,Rap鸟嘌呤核苷酸交换因子(GEF)5抗体

产品编号HZ-11582R
英文名称RAPGEF5/Repac
中文名称Rap鸟嘌呤核苷酸交换因子(GEF)5抗体
别 名GFR; Guanine nucleotide exchange factor for Rap1; KIAA0277; M Ras regulated Rap GEF; M-Ras-regulated Rap GEF; MR GEF; MR-GEF; MRGEF; Rap guanine nucleotide exchange factor 5; Rapgef5; Related to Epac; Repac; RPGF5_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 神经生物学 信号转导 转录调节因子 G蛋白偶联受体 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
RAPGEF5/Repac,Rap鸟嘌呤核苷酸交换因子(GEF)5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量68kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human RAPGEF5 (151-250aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RAPGEF5/Repac,Rap鸟嘌呤核苷酸交换因子(GEF)5抗体PubMedPubMed
产品介绍background:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Function:
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed with highest levels in brain.

Similarity:
Contains 1 N-terminal Ras-GEF domain.
Contains 1 Ras-GEF domain.

Database links:
Entrez Gene: 9771 Human
Entrez Gene: 217944 Mouse
Entrez Gene: 362799 Rat
Omim: 609527 Human
SwissProt: Q92565 Human
SwissProt: Q8C0Q9 Mouse
SwissProt: P83900 Rat
Unigene: 174768 Human
Unigene: 713217 Human
Unigene: 227642 Mouse
Unigene: 22381 Rat

RAPGEF5/Repac,Rap鸟嘌呤核苷酸交换因子(GEF)5抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.