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上海信裕生物科技有限公司
CYC1抗体

CYC1抗体

商家询价

产品名称： CYC1抗体

英文名称： CYC1Antibody

产品编号： XY 10242-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 CYC1抗体

Applications
In-house applications ELISA, WB, IHC     Application not tested? Please see our Guarantee.
Published applications WB Publications 9 citations –view here
Species specificity Human; other species not tested.
Published Species Human, macaques, mouse
Images
Prev1NextView more validation data
  • 10242-1-AP;human brain tissuehuman brain tissue were subjected to SDS PAGE followed by western blot with 10242-1-AP(CYC1 antibody) at dilution of 1:300
  • 10242-1-AP;Breast cancerImmunohistochemical of paraffin-embedded human breast cancer using 10242-1-AP(CYC1 antibody) at dilution of 1:100 (under 10x lens)
  • 10242-1-AP;Breast cancerImmunohistochemical of paraffin-embedded human breast cancer using 10242-1-AP(CYC1 antibody) at dilution of 1:100 (under 40x lens)
Positive WB detected in Human brain tissue
Positive IHC detected in Human breast cancer tissue
Recommended dilution WB : 1:500-1:5000
IHC : 1:20-1:200
 CYC1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen CYC1 fusion protein ag0291 Full name Cytochrome c-1
Calculated molecular
weight		 35 kDa Observed molecular 
weight		 35 kDa
GenBank accession 
number		 BC001006 Gene ID (NCBI) 1537
Gene symbol CYC1 Synonyms Complex III subunit 4, Complex III subunit IV, CYC1, cytochrome c 1, UQCR4
Background CYC1抗体

CYC1, also named as Cytochrome c-1, belongs to the cytochrome c family. Cytochrome c1 is one respiratory subunit of the 11 subunits of the cytochrome bc1 complex of the mitochondrial electron-transfer chain. It mediates the transfer of an electron from Rieske iron-sulfur protein to cytochrome c(PMID:3036122 ). CYC1 mediates apoptosis. In this pathway, a variety of apoptotic stimuli cause CYC1 release from mitochondria, which in turn induces a series of biochemical reactions that result incaspase activation and subsequent cell death.(PMID:15189137) While CYC1 release and DNA fragmentation are unaffected by the noncleavablep75 mutant, mitochondrial morphology of dying cells is maintained, and loss of plasma membrane integrity is delayed(PMID:15186778). The protein migrated as a 35 kd band in SDS page. CYC1抗体

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