Alpha-1-Antitrypsin抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
Alpha-1-Antitrypsin抗体

Alpha-1-Antitrypsin抗体

商家询价

产品名称： Alpha-1-Antitrypsin抗体

英文名称： Alpha-1-AntitrypsinAntibody

产品编号： XY16382-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 ALPHA-1-ANTITRYPSIN抗体

Applications
In-house applications ELISA, IHC, WB, IP, FC     Application not tested? Please see our Guarantee.
Published applications WB Publications 3 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human, MOUSE
Images
Prev12NextView more validation data
  • 16382-1-AP;mouse kidney tissuemouse kidney tissue were subjected to SDS PAGE followed by western blot with 16382-1-AP(Alpha-1-Antitrypsin antibody) at dilution of 1:1000
  • 16382-1-AP;human liver tissueImmunohistochemical of paraffin-embedded human liver using 16382-1-AP(Alpha-1-Antitrypsin antibody) at dilution of 1:50 (under 10x lens)
  • 16382-1-AP;human liverImmunohistochemical of paraffin-embedded human liver using 16382-1-AP(Alpha-1-Antitrypsin antibody) at dilution of 1:50 (under 40x lens)
  • 16382-1-AP;mouse kidney tissueIP Result of anti-Alpha-1-Antitrypsin (IP:16382-1-AP, 4ug; Detection:16382-1-AP 1:1000) with mouse kidney tissue lysate 7200ug.
  • 16382-1-AP;HepG2 cells1X10^6 HepG2 cells were stained with 0.2ug Alpha-1-Antitrypsin antibody (16382-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.
Positive WB detected in Mouse kidney tissue, human kidney tissue, mouse liver tissue, mouse lung tissue, mouse skin tissue
Positive IP detected in Mouse kidney tissue
Positive IHC detected in Human liver tissue
Positive FC detected in HepG2 cells
Recommended dilution WB : 1:500-1:5000
IP : 1:500-1:5000
IHC : 1:20-1:200
 ALPHA-1-ANTITRYPSIN抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information ALPHA-1-ANTITRYPSIN抗体
Immunogen Alpha-1-Antitrypsin fusion protein ag9369 Full name Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Calculated molecular
weight		 418aa,47 kDa Observed molecular 
weight		 40 kDa,45-53 kDa
GenBank accession 
number		 BC015642 Gene ID (NCBI) 5265
Gene symbol SERPINA1 Synonyms A1A, A1AT, AAT, Alpha 1 antiproteinase, Alpha 1 antitrypsin, Alpha 1 protease inhibitor, PI, PI1, PRO2209, PRO2275, Serpin A1, SERPINA1, SPAAT, α1-antitrypsin
Background

SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease. ALPHA-1-ANTITRYPSIN抗体
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