Tal1,T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体

产品编号HZ-9428R
英文名称Tal1
中文名称T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体
别 名bHLHa17; Class A basic helix-loop-helix protein 17; SCL antibody; Stem cell protein; T cell acute lymphocytic leukemia 1; T cell acute lymphocytic leukemia 1 protein; T cell leukemia/lymphoma 5 protein; T-cell acute lymphocytic leukemia protein 1; T-cell leukemia/lymphoma protein 5; Tal 1; Tal 1 product; TAL 1 protein; TAL-1; tal1; TAL1_HUMAN; TCL 5; TCL5.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 发育生物学 信号转导 干细胞 细胞周期蛋白 细胞分化 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
Tal1,T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Tal1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Tal1,T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体PubMedPubMed
产品介绍background:
Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.

Function:
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3.

Subcellular Location:
Nucleus.

Tissue Specificity:
Leukemic stem cell.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

Gene ID:
6886

Tal1,T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体Database links:
Entrez Gene: 6886 Human
Omim: 187040 Human
SwissProt: P17542 Human
Unigene: 705618 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.