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上海信裕生物科技有限公司
AIM2抗体

AIM2抗体

商家询价

产品名称： AIM2抗体

英文名称： AIM2Antibody

产品编号： XY20590-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 AIM2抗体

Applications
Tested Applications: ELISA, WB, IHC
Cited applications WB
Specificity Reaction: Human; Other species are not tested.Please decide the specificity by homology
Cited species Human
Positive WB detected in K-562 cells, A549 cells, COLO 320 cells, HeLa cells, HepG2 cells, Jurkat cells, MCF7 cells, SH-SY5Y cells
Positive IHC detected in Human testis tissue
Recommended dilution WB : 1:500-1:5000
IHC : 1:20-1:200
 AIM2抗体Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
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  • 20590-1-AP;K-562 cellsK-562 cells were subjected to SDS PAGE followed by western blot with 20590-1-AP(AIM2 antibody) at dilution of 1:1000
  • 20590-1-AP;human testisImmunohistochemical of paraffin-embedded human testis using 20590-1-AP(AIM2 antibody) at dilution of 1:100 (under 10x lens)
Product Information
Source: Rabbit Purify: Antigen affinity purification
IsoType: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles.
Immunogen Information AIM2抗体
Immunogen: AIM2 fusion protein ag14520 Full Name: Absent in melanoma 2
Caculated Molecular
Weight:		 343aa,39 kDa Observed Molecular 
Weight:		 40-45kd
GenbankNo BC010940 GeneID: 9447
Symbol AIM2 Synonyms Absent in melanoma 2, AIM2, PYHIN4
Background

Absent in melanoma 2 (AIM2) is a sensor of cytosolic DNA that is responsible for activation of the inflammasome and host immune responses to DNA viruses and intracellular bacteria [PMID: 22695634]. Upon binding to DNA, it is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Otherwise, it functions as a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity [PMID:16432157,20566831]. AIM2抗体
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