FITC标记的Toll样受体8抗体
产品名称： FITC标记的Toll样受体8抗体
英文名称： Anti-TLR8/FITC
产品编号： HZ-8684R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TLR8/FITC Conjugated antibody
FITC标记的Toll样受体8抗体
| 产品编号 | bs-8684R-FITC |
| 英文名称 | Anti-TLR8/FITC |
| 中文名称 | FITC标记的Toll样受体8抗体 |
| 别 名 | CD 288; CD288; CD288 antigen; MGC119599; MGC119600; TLR 8; TLR-8; Tlr8; TLR8_HUMAN; Toll Like Receptor 8; Toll-like receptor 8. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 细胞周期蛋白 细胞膜受体 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 117kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TLR 8 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Toll-like Receptors (TLR) are a family of human receptors that share homology with the Drosophila Toll Receptors, which are involved in mediating dorsoventral polarization in developing Drosophila embryos and participate in host immunity. The TLR family members are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transductions. TLRs are type I transmembrane receptors that contain an extracellular domain consisting of several leucine-rich regions and a single cytoplasmic Toll/IL-1R like domain. Three TLR family members, TLR7, TLR8 and TLR9, belong to a subfamily of TLRs which are differentially expressed. TLR7 is expressed in lung, placenta and spleen. TLR8 is expressed in lung and peripheral blood leukocytes, and TLR9 is predominantly expressed in spleen, lymph nodes, bone marrow and peripheral blood leukocytes. TLR7, TLR8 and TLR9 stimulate the NFkB signaling pathway, suggesting that they play a role in the immune response. Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Subunit: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). Interacts with BTK. Subcellular Location: Membrane. Tissue Specificity: Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells. Similarity: Belongs to the Toll-like receptor family. Contains 23 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 TIR domain. Database links: Entrez Gene: 51311 Human Entrez Gene: 170744 Mouse Entrez Gene: 684440 Rat Omim: 300366 Human SwissProt: Q9NR97 Human SwissProt: P58682 Mouse Unigene: 660543 Human Unigene: 196676 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Toll样受体（Toll样受体）是一个与果蝇Toll受体同源的人类受体家族，参与了果蝇胚胎发育中的背腹极化介导和参与宿主免疫。TLR家族成员具有高度保守的Toll同源性（TH）结构域，这是Toll诱导的信号转导所必需的。TLR是I型跨膜受体，包含胞外结构域，由多个富含亮氨酸的区域和单个细胞质Toll／IL-1R样结构域组成。三个TLR家族成员TLR7、TLR8和TLR9属于TLRs的一个亚家族，差异表达。TLR7在肺、胎盘和脾脏均有表达。TLR8在肺和外周血白细胞中表达，TLR9主要在脾脏、淋巴结、骨髓和外周血白细胞中表达。TLR7、TLR8和TLR9刺激NFKB信号通路，提示它们在免疫应答中发挥作用。