MC5 Receptor,黑素皮质素受体5抗体

产品编号HZ-11418R
英文名称MC5 Receptor
中文名称黑素皮质素受体5抗体
别 名MC-2; MC2; MC5 R; MC5-R; MC5R; MC5R_HUMAN; Melanocortin 5 receptor; Melanocortin receptor 5.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rabbit,
MC5 Receptor,黑素皮质素受体5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MC5 Receptor
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MC5 Receptor,黑素皮质素受体5抗体PubMedPubMed
产品介绍background:
The melanocortin family comprises the Alpha-, Beta- and Gamma- melanocyte stimulating hormones (MSH) and adrenocorticotrophin. The receptors for these hormones are seven-transmembrane G protein-coupled proteins that activate adenylyl cyclase. Five melanocortin receptors have been cloned and shown to exhibit different affinities and patterns of expression. MC1-R (MSH-R) is expressed in melanocytes and corticoadrenal tissue. MC2-R is the ACTH receptor and is expressed primarily in the adrenal cortex. MC3-R has been found in specific regions of the brain and is also expressed in placenta and gut. MC4-R is expressed primarily in brain, while MC5-R is expressed at low levels in most tissues.

Function:
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed in the brain but not in the melanoma cells.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Gene ID:
4161

Database links:
Entrez Gene: 4161 Human
Entrez Gene: 17203 Mouse
Entrez Gene: 25726 Rat
Omim: 600042 Human
SwissProt: P33032 Human
SwissProt: P41149 Mouse
SwissProt: P35345 Rat
Unigene: 248145 Human
Unigene: 8003 Mouse
Unigene: 9673 Rat

MC5 Receptor,黑素皮质素受体5抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.