Fascin-3,肌动蛋白结合蛋白Fascin3抗体

产品编号HZ-11285R
英文名称Fascin-3
中文名称肌动蛋白结合蛋白Fascin3抗体
别 名Fascin (testis); Fascin 3; Fascin homolog 3 actin bundling protein testicular (Strongylocentrotus purpuratus) ; Fascin homolog 3 actin bundling protein testicular; Fascin3; FSCN 3; FSCN3; MGC94950; Testis fascin; FSCN3_HUMAN.
说 明 书0.1ml 0.2ml
研究领域信号转导 细胞骨架 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Sheep,
Fascin-3,肌动蛋白结合蛋白Fascin3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Fascin-3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Fascin-3,肌动蛋白结合蛋白Fascin3抗体PubMedPubMed
产品介绍background:
Cell adhesion to extracellular matrix is an important physiological stimulus for organization of the Actin-based cytoskeleton. Adhesion to the matrix glycoprotein Thrombospondin 1 triggers the sustained formation of F-Actin microspikes that contain the Actin-bundling protein Fascin. These structures are also implicated in cell migration, which may be an important function of Thrombospondin 1 in tissue remodelling and wound repair. Fascin bundles Actin microfilaments within dynamic cellular structures such as microspikes, stress fibers and membrane ruffles. Fascin could serve as a prognostic factor for abnormal ovarian epithelial pathology and could be a novel target for the treatment of ovarian cancer. Fascin, an Actin-bundling protein, identifies dendritic cells in the blood and in tissues.

Function:
Acts as an actin bundling protein (By similarity).

Subcellular Location:
Cytoplasm, cytoskeleton (By similarity).

Tissue Specificity:
Expressed in testis.

Similarity:
Belongs to the fascin family.

Database links:
Entrez Gene: 29999 Human
Entrez Gene: 56223 Mouse
SwissProt: Q9NQT6 Human
SwissProt: Q9QXW4 Mouse
Unigene: 712692 Human
Unigene: 31708 Mouse

Fascin-3,肌动蛋白结合蛋白Fascin3抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.