Anti-GPER1 Polyclonal Antibody

品牌：solarbio | 货号：K101555P

商品货号：	商品品牌：	规格	基本售价：	选择规格
K101555P-50ul	solarbio	50ul	960.00元
K101555P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-GPER1 Polyclonal Antibody
别名	CEPR;CMKRL2;DRY12;FEG-1;GPCR-Br;GPER;GPR30;LERGU;LERGU2;LyGPR;mER
应用	WB
稀释比例	WB 1:3000.
交叉反应	Human Mouse Rat
蛋白分子量	42kDa
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	A synthetic peptide of human GPER1
性状	液体
Public Immunogen Range	A synthetic peptide of human GPER1
Subcellular Locations	Basolateral cell membrane Cell junction Cell membrane Cell projection Cytoplasm Cytoplasmic vesicle membrane Early endosome Endoplasmic reticulum membrane Golgi apparatus Golgi apparatus membrane Mitochondrion membrane Multi-pass membrane protein Nucleus Recycling endosome axon cytoskeleton dendrite dendritic spine membrane perinuclear region postsynaptic cell membrane postsynaptic density synapse trans-Golgi network
Swiss Prot	Q99527
克隆类型	Polyclonal Antibody
背景资料	G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.