FITC标记的透明质酸合成酶3抗体
产品名称： FITC标记的透明质酸合成酶3抗体
英文名称： Anti-HAS3/FITC
产品编号： HZ-11052R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HAS3/FITC Conjugated antibody
FITC标记的透明质酸合成酶3抗体
| 产品编号 | bs-11052R-FITC |
| 英文名称 | Anti-HAS3/FITC |
| 中文名称 | FITC标记的透明质酸合成酶3抗体 |
| 别 名 | HA synthase 3; HAS3; HAS 3; HAS-3; HAS3_HUMAN; Hyaluronan synthase 3; Hyaluronate synthase 3; Hyaluronic acid synthase 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 干细胞 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 61kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HAS3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: HAS1, HAS2 and HAS3 are HA (hyaluronan or hyaluronic acid) synthase proteins. The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by b-1,3 and b-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesize high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli, suggesting distinct functional roles of the three proteins. HAS3 produces both secreted and cell-associated forms of hyaluronan and is the most active of the three isoforms of this enzyme in adults. HAS3 gene expression plays a crucial role in the regulation of hyaluronan synthesis in the epidermis. Specifically, IFN-g markedly upregulates HAS3 mRNA, whereas TGF Beta downregulates HAS3 transcript levels. The human HAS3 gene maps to chromosome 16q22.1. Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Subcellular Location: Membrane; Multi-pass membrane protein (Probable). Similarity: Belongs to the nodC/HAS family. Database links: Entrez Gene: 3038 Human Entrez Gene: 15118 Mouse Entrez Gene: 266805 Rat Omim: 602428 Human SwissProt: O00219 Human SwissProt: O08650 Mouse Unigene: 592069 Human Unigene: 56986 Mouse Unigene: 163402 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
HAS1、HAS2和HAS3是HA（透明质酸或透明质酸）合酶蛋白。大多数脊椎动物的细胞外基质表达HA，它是由B- 1,3和B-1,4糖苷键连接的葡萄糖醛酸和N-乙酰氨基葡萄糖残基组成的高分子量线性多糖。三个基因在发育过程中表现出不同的表达模式，它们的蛋白产物在HA基质的形成中发挥显著不同的作用。HAS1和HAS2均合成高分子量HA，而HAS3则产生较低的分子量HA。三的表达在生长的细胞中比在静息细胞中更为突出，并且受到不同刺激的差异调节，提示三种蛋白质的不同功能作用。HAS3产生透明质酸分泌的和细胞相关的形式，是该酶在成人中的三种亚型中最活跃的。HAS3基因的表达在表皮透明质酸合成调控中起重要作用。具体而言，IFN-γ显著上调HAS3 mRNA，而TGF-β下调HAS3转录水平。人类HAS3基因定位于染色体16q22.1。