OCT6,八聚体结合转录因子6抗体

产品编号HZ-11203R
英文名称OCT6
中文名称八聚体结合转录因子6抗体
别 名transcription factor 1; OCT 6; OCT 6; OCT-6; OCT-6; OCT6; OCT6; Octamer-binding protein 6; Octamer-binding transcription factor 6; OTF-6; OTF6; OTF6; PO3F1_HUMAN; POU class 3 homeobox 1; POU domain; POU domain class 3 transcription factor 1; POU domain class 3 transcription factor 1; POU domain transcription factor SCIP; POU-domain transcription factor SCIP; POU3F1; POU3F1; scip (gene name); SCIP.
说 明 书0.1ml 0.2ml
研究领域神经生物学 干细胞 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit, Sheep,
OCT6,八聚体结合转录因子6抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量45kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human OCT6
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
OCT6,八聚体结合转录因子6抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the organic zwitterions transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011].

Function:
High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.

Subcellular Location:
Membrane; Multi-pass membrane protein (Potential). Cell membrane. Note=Detected in the plasma mebrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis.

Tissue Specificity:
Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase.

Similarity:
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Gene ID:
5453

OCT6,八聚体结合转录因子6抗体Database links:
Entrez Gene: 5453 Human
Entrez Gene: 18991 Mouse
Entrez Gene: 192110 Rat
Omim: 602479 Human
SwissProt: Q03052 Human
SwissProt: P21952 Mouse
SwissProt: P20267 Rat
Unigene: 1837 Human
Unigene: 297371 Mouse
Unigene: 82720 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.