DGAT2L4,二酰基甘油酰基转移酶2样蛋白4抗体

产品编号HZ-14290R
英文名称DGAT2L4
中文名称二酰基甘油酰基转移酶2样蛋白4抗体
别 名Acyl CoA wax alcohol acyltransferase 2; acyl-CoA retinol O-fatty-acyltransferase; ARAT; AWAT2; DC4; Diacylglycerol O acyltransferase 2 like 4; Diacylglycerol O acyltransferase candidate 4; diacylglycerol O-acyltransferase 2-like protein 4; hWS; Long chain alcohol O fatty acyltransferase 2; MFAT; Multifunctional O acyltransferase; retinol O-fatty-acyltransferase; Wax synthase 2; Wax synthase; WS.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 信号转导 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
DGAT2L4,二酰基甘油酰基转移酶2样蛋白4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DGAT2L4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DGAT2L4,二酰基甘油酰基转移酶2样蛋白4抗体PubMedPubMed
产品介绍background:
This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]

Function:
Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2 acylglycerol O acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo.

Subcellular Location:
Endoplasmic reticulum membrane; Multipass membrane protein.

Tissue Specificity:
Abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid. Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas.

Similarity:
Belongs to the diacylglycerol acyltransferase family.

Gene ID:
158835

DGAT2L4,二酰基甘油酰基转移酶2样蛋白4抗体Database links:
Entrez Gene: 158835 Human
Entrez Gene: 245532 Mouse
Entrez Gene: 302425 Rat
SwissProt: Q6E213 Human
SwissProt: Q6E1M8 Mouse
Unigene: 661507 Human
Unigene: 118171 Mouse
Unigene: 220750 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.