ICMT,异戊烯半胱氨酸羧基甲基转移酶抗体

产品编号HZ-8019R
英文名称ICMT
中文名称异戊烯半胱氨酸羧基甲基转移酶抗体
别 名HSTE14; Icmt; ICMT_HUMAN; Isoprenylcysteine carboxylmethyltransferase; MGC39955; MGC95322; MST098; MSTP098; pcCMT; PCMT; PPMT; Prenylated protein carboxyl methyltransferase; Prenylcysteine carboxyl methyltransferase; Protein-S-isoprenylcysteine O-methyltransferase; RP23-421E12.4; STE14; fcmt.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
ICMT,异戊烯半胱氨酸羧基甲基转移酶抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量32kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CMT/Icmt
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ICMT,异戊烯半胱氨酸羧基甲基转移酶抗体PubMedPubMed
产品介绍background:
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.

Function:
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Subcellular Location:
Endoplasmic reticulum membrane.

Tissue Specificity:
Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.

Similarity:
Belongs to the isoprenylcysteine O-methyltransferase family.

Database links:
UniProtKB/Swiss-Prot: O60725.1

ICMT,异戊烯半胱氨酸羧基甲基转移酶抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Icmt酶是异戊烯途径中的一种关键酶，它能将甲基加到Ras上。这种甲基标签能使Ras到达细胞中的最终目的地，Icmt酶能发送不控制生长的信号，因此，Icmt蛋白在保持细胞中的致癌基因Ras的开启状态中起到重要作用。（Ras是细胞的一种正常的遗传成分，但是这种基因的突变能够致使它促进细胞的失控生长。而且，在一半的结肠癌和90％的胰腺癌中发生了Ras基因突变）。