Synaptogyrin 3,神经细胞囊泡循环蛋白3抗体

产品编号HZ-11373R
英文名称Synaptogyrin 3
中文名称神经细胞囊泡循环蛋白3抗体
别 名SNG3_HUMAN; Synaptogyrin 3; Synaptogyrin-3; Synaptogyrin3; SYNGR 3; SYNGR3; SYNGR-3; MGC:20003; MGC20003; OTTHUMP00000158899.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
Synaptogyrin 3,神经细胞囊泡循环蛋白3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Synaptogyrin 3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Synaptogyrin 3,神经细胞囊泡循环蛋白3抗体PubMedPubMed
产品介绍background:
The synaptogyrin family of proteins are integral membrane proteins containing four transmembrane regions. Synaptogyrins are tyrosine-phosphorylated proteins with two neuronal (Synaptogyrins 1 and 3) and one ubiquitous (Synaptogyrin-2) isoform. Synaptophysin and synaptogyrin represent the major constituents of synaptic vesicles. Synaptogyrin-1 is associated with presynaptic vesicles in neuronal cells. Synaptogyrin-2, also known as Cellugyrin has a tyrosine phosphorylated C-terminal cytoplasmic tail, and is involved in the regulation of membrane traffic in non-neuronal cells. Synaptogyrin-3 is expressed mainly in brain and placenta. The SYNGR4 gene encodes for the 234 amino acid protein Synaptogyrin-4.

Function:
Involved in the positive regulation of dopamine transporter activity. Probably facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release.

Subunit:
Interacts (via N-terminus) with SLC6A3 (via N-terminus) (By similarity).

Subcellular Location:
Membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle (By similarity). Cell junction, synapse. Note=Found at the neuromuscular synapses (By similarity).

Tissue Specificity:
Expressed in brain and placenta.

Synaptogyrin 3,神经细胞囊泡循环蛋白3抗体Similarity:
Belongs to the synaptogyrin family.
Contains 1 MARVEL domain.

Database links:
UniProtKB/Swiss-Prot: O43761.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.