Semaphorin 5B,跨膜蛋白SEMA5B抗体

产品编号HZ-11482R
英文名称Semaphorin 5B
中文名称跨膜蛋白SEMA5B抗体
别 名SEM5B_HUMAN; SEMA5B; SEMAG; Semaphorin-5B; Semaphorin 5B; Semaphorin5B; SemG.
说 明 书0.1ml 0.2ml
研究领域发育生物学 神经生物学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
Semaphorin 5B,跨膜蛋白SEMA5B抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量126kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SEMA5B/Semaphorin 5B (146-195aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Semaphorin 5B,跨膜蛋白SEMA5B抗体PubMedPubMed
产品介绍background:
Semaphorins are a family of cell surface and secreted proteins that are conserved from insects to humans. Members of this family of proteins are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin” domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. Secreted and cell-bound semaphorins chemically attract and repel the growth of neural axons, guiding the development of intricate networks of neural tissue. SEMA5B (semaphorin-5B), also known as SEMAG, is a 1151 amino acid member of the semaphorin family. Localized to the membrane, SEMA5B is a single-pass type III protein that functions to convey positive axonal guidance cues and can induce calpain-mediated cleavage of calcineurin. Three isoforms exist due to alternative splicing events.

Function:
May act as positive axonal guidance cues.

Subcellular Location:
Membrane; Single-pass type III membrane protein.

Similarity:
Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.
Contains 5 TSP type-1 domains.

Semaphorin 5B,跨膜蛋白SEMA5B抗体Database links:
Entrez Gene: 54437 Human
Omim: 609298 Human
SwissProt: Q9P283 Human
Unigene: 210870 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.