GCOM1/GRINL1A,GCOM1蛋白抗体

产品编号HZ-8403R
英文名称GCOM1/GRINL1A
中文名称GCOM1蛋白抗体
别 名Gcom2; Glutamate receptor ionotropic N methyl D aspartate like 1A combined; GRINL1A; GRINL1A combined protein; GRINL1A combined protein Gcom12; GRINL1A upstream protein; Gup1; Gup2; NMDAR1 subunit interacting protein.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
GCOM1/GRINL1A,GCOM1蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量62kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human GCOM1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
GCOM1/GRINL1A,GCOM1蛋白抗体PubMedPubMed
产品介绍background:
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Synaptic and extrasynaptic NMDA receptors have been shown to have opposite effects on neuronal survival, CREB function and gene regulation. Gcom1 (GRINL1A complex locus protein 1), also known as GUP (GRINL1A upstream protein) and Gcom (GRINL1A combined protein), is a 466 amino acid protein that is a component of the GRINL1A complex transcription unit, which is thought to be involved in the modulation of glutamatergic neurotransmission through interaction with the NR1 subunit of the NMDA receptor. Gcom1 is expressed in small intestine, lung, liver, heart, skeletal muscle, testis and prostate and also colocalizes with NR1 in cortical and hippocampal neurons. There are eleven isoforms of Gcom1 that are produced as a result of alternative splicing events.

Database links:
Entrez Gene: 81488 Human
Entrez Gene: 28015 Mouse
Entrez Gene: 192147 Rat
Omim: 606485 Human
SwissProt: P0CAP2 Human
SwissProt: Q6P6I6 Mouse
SwissProt: Q91XQ4 Rat

GCOM1/GRINL1A,GCOM1蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片	Sample: Heart (Mouse)Lysate at 40 ug Uterus (Mouse)Lysate at 40 ug Primary: Anti-GCOM1'GRINL1A(HZ-8403R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 62kD Observed band size: 62kD