GPR40,G蛋白偶联受体40抗体

产品编号HZ-9564R
英文名称GPR40
中文名称G蛋白偶联受体40抗体
别 名GPCR GPR40; FFA1R; FFAR 1; FFAR1; Free fatty acid receptor 1; G protein coupled receptor 40; GPR 40; FFAR1_HUMAN; GPCR40.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 信号转导 G蛋白偶联受体 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig,
GPR40,G蛋白偶联受体40抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human G protein coupled receptor 40
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
GPR40,G蛋白偶联受体40抗体PubMedPubMed
产品介绍background:
G protein coupled receptors provide attractive targets for drug therapy due to the sheer size and diversity of ligands within this receptor family. G protein-coupled receptor 40 (GPR40) functions as a cell-surface receptor for long-chain free fatty acids (FFAs). FFAs provide an important energy source, but also function as signaling molecules in various pathways, notably the process of insulin secretion. In pancreatic tissue, the interaction of long chain FFAs with GPR40 amplifies glucose-stimulated insulin secretion from beta cells, suggesting a possible role for GPR40 in the treatment of diabetes associated with insulin-deficiency. Specifically, the Arg211His polymorphism in the GPR40 gene may contribute to the variation of insulin secretory capacity in Japanese men. Also, GPR40 may be involved in the control of breast cancer cell growth by fatty acids and, therefore, provide a link between fat and cancer.

Function:
Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.

Subcellular Location:
Membrane; multi pass membrane protein.

Tissue Specificity:
Expressed abundantly in pancreatic beta cells

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:
Entrez Gene: 2864 Human
Entrez Gene: 233081 Mouse
Entrez Gene: 266607 Rat
Omim: 603820 Human
SwissProt: O14842 Human
SwissProt: Q76JU9 Mouse
SwissProt: Q8K3T4 Rat
Unigene: 248127 Human
Unigene: 425422 Mouse
Unigene: 86438 Rat

GPR40,G蛋白偶联受体40抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.