CYLC2,CYLC2蛋白抗体

产品编号HZ-14142R
英文名称CYLC2
中文名称CYLC2蛋白抗体
别 名CYL2; CYLC 2; Cylicin 2; Cylicin basic protein of sperm head cytoskeleton 2; Cylicin II; Cylicin2; Cylicin-2; MGC129591; Multiple band polypeptide II.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 干细胞 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
CYLC2,CYLC2蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CYLC2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CYLC2,CYLC2蛋白抗体PubMedPubMed
产品介绍background:
Cylicin-2 is a 348 amino acid protein encoded by the human gene CYLC2. Cylicin-1 is a type of a cytoskeletal protein which contains numerous Lys-Lys-Asp tripeptides accumulated in nine central repetitive units predicted to form a-helices. Cylicin-2, present in cow and human sperm heads, has the same prominent molecular characteristics as Cylicin-1, including a high content of charged amino acids, the abundance of Lys-Lys-Asp tripeptides and repetitive units of presumably a-helical configuration. Cylicin-2 is found in the acrosomal region of round spermatids and in the post-acrosomal region of late spermatids and spermatozoa, in agreement with the localization of Cylicin-1. Cylicin-2 is a novel Actin-binding protein, which probably plays a role in the Actin-related events that occur during spermiogenesis and the early events of fertilization.

Function:
CYCL2 (Cylicin II) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head and may be involved in spermatid differentiation.

Subcellular Location:
Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.

Tissue Specificity:
Testis.

Gene ID:
1537

Database links:
Entrez Gene: 1537 Human
Entrez Gene: 1539 Human
Omim: 604035 Human
SwissProt: P08574 Human
SwissProt: Q14093 Human

CYLC2,CYLC2蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.