Unc5a,神经突起生长诱导因子受体Unc5a抗体

产品编号HZ-11495R
英文名称Unc5a
中文名称神经突起生长诱导因子受体Unc5a抗体
别 名UNC5H1; Netrin receptor UNC 5A; Netrin receptor UNC5A; Netrin receptor Unc5h1; Protein unc-5 homolog 1; Protein unc-5 homolog A; Unc 5 homolog 1; Unc 5 homolog A; Unc 5a; Unc5 a; Unc5 homolog 1; Unc5 homolog A; Unc5a; UNC5A_HUMAN; Unc5h1; FLJ16449; KIAA1976.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 神经生物学 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
Unc5a,神经突起生长诱导因子受体Unc5a抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量90kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Unc5a
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Unc5a,神经突起生长诱导因子受体Unc5a抗体PubMedPubMed
产品介绍background:
The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.

Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Subunit:
Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC

Subcellular Location:
Cell membrane. The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones.

Post-translational modifications:
Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro.
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.

Unc5a,神经突起生长诱导因子受体Unc5a抗体Similarity:
Belongs to the unc-5 family.
Contains 1 death domain.
Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TSP type-1 domain.
Contains 1 ZU5 domain.

Database links:
Entrez Gene: 90249 Human
Entrez Gene: 107448 Mouse
Entrez Gene: 60629 Rat
Omim: 607869 Human
SwissProt: Q6ZN44 Human
SwissProt: Q8K1S4 Mouse
SwissProt: O08721 Rat
Unigene: 33191 Human
Unigene: 23573 Mouse
Unigene: 44433 Rat

Unc5a,神经突起生长诱导因子受体Unc5a抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.