ALPHA-2-MACROGLOBULIN抗体
Applications
| In-house applications |
ELISA, WB, IHC, IP, IF Application not tested? Please see our Guarantee. |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
|
Images
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 human blood tissue were subjected to SDS PAGE followed by western blot with 13545-1-AP(A2M antibody) at dilution of 1:6000 IP Result of anti-A2M (IP:13545-1-AP, 5ug; Detection:13545-1-AP 1:300) with HepG2 cells lysate 2800ug. Immunohistochemistry of paraffin-embedded human hepatocirrhosis tissue slide using 13545-1-AP( A2M Antibody) at dilution of 1:50 (under 10x lens) Immunohistochemistry of paraffin-embedded human hepatocirrhosis tissue slide using 13545-1-AP( A2M Antibody) at dilution of 1:50 (under 40x lens) Immunofluorescent analysis of ( -20℃ Ethanol ) fixed HepG2 cells using 13545-1-AP( A2M Antibody) at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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| Positive WB detected in |
Human blood tissue, HepG2 cells, human brain tissue, human serum tissue |
| Positive IP detected in |
HepG2 cells |
| Positive IHC detected in |
Human hepatocirrhosis tissue, human ovary tissue, human stomach tissue |
| Positive IF detected in |
HepG2 cells |
| Recommended dilution |
WB : 1:2000-1:20000
IP : 1:200-1:1000
IHC : 1:20-1:200
IF : 1:50-1:500 |
ALPHA-2-MACROGLOBULIN抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen |
Alpha-2-macroglobulin fusion protein ag4489 |
Full name |
Alpha-2-macroglobulin |
Calculated molecular
weight |
1474aa,163 kDa |
Observed molecular
weight |
185 kDa |
GenBank accession
number |
BC040071 |
Gene ID (NCBI) |
2 |
| Gene symbol |
A2M |
Synonyms |
A2M, Alpha 2 M, alpha 2 macroglobulin, CPAMD5, DKFZp779B086, FWP007, S863 7, α-2M |
Background ALPHA-2-MACROGLOBULIN抗体
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Alpha-2-macroglobulin, also known as α2-macroglobulin (α2M or A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. A2M is an evolutionarily conserved arm of the innate immune system. It also mediates the proliferation of T cells and macrophages. A2M acts as a nonspecific protease inhibitor involved in the host defense mechanism that inactivates both endogenous and exogenous proteases, including trypsin, thrombin and collagenase. Even though A2M is produced predominantly by the liver, it may also be expressed in the reproductive tract, heart, and brain, and may have important roles in many physiological processes and medical illnesses including Alzheimer’s disease. ALPHA-2-MACROGLOBULIN抗体
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