Ghrelin Receptor,脑肠肽受体抗体

产品编号HZ-11529R
英文名称Ghrelin Receptor
中文名称脑肠肽受体抗体
别 名GH releasing peptide receptor; GH-releasing peptide receptor; Ghrelin receptor; GHRP; GHRPR; GHS-R; GHS-R1; GHSR; GHSR_HUMAN; Growth hormone secretagogue receptor 1; Growth hormone secretagogue receptor type 1; growth hormone secretatgogue receptor.
说 明 书0.1ml 0.2ml
研究领域肿瘤 神经生物学 信号转导 生长因子和激素 细胞膜受体 G蛋白偶联受体 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
Ghrelin Receptor,脑肠肽受体抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量41kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Ghrelin Receptor (75-135aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Ghrelin Receptor,脑肠肽受体抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the G-protein coupledreceptor family. The encoded protein may play a role in energyhomeostasis and regulation of body weight. Two identifiedtranscript variants are expressed in several tissues and areevolutionary conserved in fish and swine. One transcript, 1a,excises an intron and encodes the functional protein; this proteinis the receptor for the Ghrelin ligand and defines a neuroendocrinepathway for growth hormone release. The second transcript (1b)retains the intron and does not function as a receptor for Ghrelin;however, it may function to attenuate activity of isoform 1a.Mutations in this gene are associated with autosomal idiopathicshort stature.[provided by RefSeq, Apr 2010].

Function:
Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

Subcellular Location:
Cell membrane.

Tissue Specificity:
Pituitary and hypothalamus.

DISEASE:
Defects in GHSR may be a cause of idiopathic short stature autosomal (ISSA) [MIM:604271]. Short stature is defined by a subnormal rate of growth.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Ghrelin Receptor,脑肠肽受体抗体SWISS:
Q6ISR8

Gene ID:
2693

Database links:
Entrez Gene: 2693 Human
Entrez Gene: 208188 Mouse
Entrez Gene: 397372 Pig
Entrez Gene: 84022 Rat
Omim: 601898 Human
SwissProt: Q6ISR8 Human
SwissProt: Q92847 Human
SwissProt: Q99P50 Mouse
SwissProt: Q95254 Pig
SwissProt: O08725 Rat
Unigene: 130212 Human
Unigene: 194721 Mouse
Unigene: 16107 Pig
Unigene: 74241 Rat

Ghrelin Receptor,脑肠肽受体抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片	Western blot analysis of extracts from Ht-29 cells using Ghrelin Receptor Antibody. Western blot analysis of extracts from Sw480 cells using Ghrelin Receptor Antibody.