LRRTM3,富含亮氨酸重复跨膜神经元蛋白3抗体

产品编号HZ-11571R
英文名称LRRTM3
中文名称富含亮氨酸重复跨膜神经元蛋白3抗体
别 名Leucine rich repeat transmembrane neuronal protein 3; Leucine-rich repeat transmembrane neuronal protein 3; LRRT3_HUMAN; Lrrtm3; MGC131810; PRO1693; UNQ803.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 细胞膜受体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep, Monkey,
LRRTM3,富含亮氨酸重复跨膜神经元蛋白3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量63kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human LRRTM3 (31-120aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
LRRTM3,富含亮氨酸重复跨膜神经元蛋白3抗体PubMedPubMed
产品介绍background:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The LRRTM protein family plays a role in the regulation of various cellular events during nervous system development. Localizing predominantly to the nervous system, LRRTM family members are known to exhibit synaptogenic activity. LRRTM3 (leucine rich repeat transmembrane neuronal 3) is a 581 amino acid single-pass type I membrane protein belonging to the LRRTM family. LRRTM3 is involved in the development and maintenance of the vertebrate nervous system, and contains ten LRR repeats. Expressed in neuronal tissues, LRRTM3 is encoded by a gene that maps to a region of chromosome 10 that has been linked to late-onset Alzheimer disease and elevated plasma Beta-Amyloid. As a result of alternative splicing events, two LRRTM3 isoforms exist.

Function:
May play a role in the development and maintenance of the vertebrate nervous system.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein

Tissue Specificity:
Expressed in neuronal tissues.

LRRTM3,富含亮氨酸重复跨膜神经元蛋白3抗体Similarity:
Belongs to the LRRTM family.
Contains 10 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Database links:
UniProtKB/Swiss-Prot: Q86VH5.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.