phospho-FXYD1 (Ser83),磷酸化磷酸神经膜抗体

产品编号HZ-5348R
英文名称phospho-FXYD1 (Ser83)
中文名称磷酸化磷酸神经膜抗体
别 名FXYD1 (phospho S83); FXYD1 (phospho Ser83); p-FXYD1 (phospho S83); FXYD domain containing ion transport regulator 1; Phospholemman; PLM; fxyd1; PLM_HUMAN; FXYD domain-containing ion transport regulator 1.
说 明 书0.1ml
产品类型磷酸化抗体
研究领域免疫学 神经生物学 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
phospho-FXYD1 (Ser83),磷酸化磷酸神经膜抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量10kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human FXYD1 around the phosphorylation site of Ser83
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
phospho-FXYD1 (Ser83),磷酸化磷酸神经膜抗体PubMedPubMed
产品介绍background:
PLM (FXYD1)is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. PLM may be phosphorylated by several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity.

Function:
May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis.

phospho-FXYD1 (Ser83),磷酸化磷酸神经膜抗体Post-translational modifications:
Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues (By similarity). Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK.
Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA.

Similarity:
Belongs to the FXYD family.

Gene ID:
5348

Database links:
Entrez Gene: 476487 Dog
Entrez Gene: 5348 Human
Entrez Gene: 56188 Mouse
Entrez Gene: 58971 Rat
Omim: 602359 Human
SwissProt: P56513 Dog
SwissProt: O00168 Human
SwissProt: Q9Z239 Mouse
SwissProt: O08589 Rat
Unigene: 442498 Human

phospho-FXYD1 (Ser83),磷酸化磷酸神经膜抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.