SRGAP1,Rho GTP酶激活蛋白13抗体

产品编号HZ-11601R
英文名称SRGAP1
中文名称Rho GTP酶激活蛋白13抗体
别 名ARHGAP13; FLJ22166; KIAA1304; RGD1566260; Rho GTPase activating protein 13; SLIT ROBO Rho GTPase activating protein 1; SRGAP 1; SRGP1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
SRGAP1,Rho GTP酶激活蛋白13抗体产品应用IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量124kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SRGAP1 (51-150aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SRGAP1,Rho GTP酶激活蛋白13抗体PubMedPubMed
产品介绍background:
SRGAPs contain a highly conserved overall primary structure and play an important role in the cell facilitating Slit-robo signaling in cell migration and axon guidance. SRGAP1 (Slit-robo Rho GTPase activating protein 1), also known as ARHGAP13 (Rho GTPase activating protein 13), functions as a GTPase-activating protein for Cdc42 and Rho A. Expressed in kidney, testis, lung and brain, SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 ultimately leads to a decrease in actin polymerization.

Function:
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

Subunit:
Homodimer (Probable). Forms heterooligomer with SRGAP2 and SRGAP3 through its F-BAR domain. Interacts with ROBO1, CDC42 and RHOA. Interacts with FASLG.

Tissue Specificity:
Expressed in brain, lung, kidney, and testis.

Similarity:
Contains 1 FCH domain.
Contains 1 Rho-GAP domain.
Contains 1 SH3 domain.

Gene ID:
57522

SRGAP1,Rho GTP酶激活蛋白13抗体Database links:
Entrez Gene: 57522 Human
Entrez Gene: 117600 Mouse
Entrez Gene: 314903 Rat
Omim: 606523 Human
SwissProt: Q7Z6B7 Human
SwissProt: Q91Z69 Mouse
Unigene: 210751 Human
Unigene: 593803 Human
Unigene: 288698 Mouse
Unigene: 208903 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.