Hippocalcin,神经细胞特异性钙结合蛋白抗体

产品编号HZ-11348R
英文名称Hippocalcin
中文名称神经细胞特异性钙结合蛋白抗体
别 名BDR 2; BDR2; Calcium binding protein BDR 2; Calcium binding protein BDR2; Calcium-binding protein BDR-2; Hpca; HPCA_HUMAN; Neuron specific calcium binding protein hippocalcin; Neuron specific calcium-binding protein hippocalcin; Neuron-specific calcium-binding protein hippocalcin; P23K.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 结合蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Cow, Rabbit,
Hippocalcin,神经细胞特异性钙结合蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Hippocalcin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Hippocalcin,神经细胞特异性钙结合蛋白抗体PubMedPubMed
产品介绍background:
Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by contributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation.

Function:
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions.

Tissue Specificity:
Brain specific.

Post-translational modifications:
Myristoylation facilitates interaction with membranes.

Similarity:
Belongs to the recoverin family.
Contains 4 EF-hand domains.

Gene ID:
3208

Hippocalcin,神经细胞特异性钙结合蛋白抗体Database links:
Entrez Gene: 3208 Human
Entrez Gene: 509772 Cow
Entrez Gene: 15444 Mouse
Entrez Gene: 29177 Rat
Omim: 142622 Human
SwissProt: Q4PL64 Cow
SwissProt: P84074 Human
SwissProt: P84075 Mouse
SwissProt: P84076 Rat
Unigene: 632391 Human
Unigene: 384452 Mouse
Unigene: 11019 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.