CD57,髓鞘相关糖蛋白CD57抗体

产品编号HZ-1635R
英文名称CD57
中文名称髓鞘相关糖蛋白CD57抗体
别 名3-glucuronyltransferase 1; 3-glucuronyltransferase; B3GA1_HUMAN; B3GAT1; Beta 1 3 glucuronyltransferase 1; Beta-1; CD 57; CD57; CD57 antigen; Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 1; Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; GlcAT P; GlcAT-P; GLCATP; GlcUAT P; GlcUAT-P; GlcUATP; Glucuronosyltransferase P; HNK 1; HNK1; LEU 7; LEU7; LEU7 antigen; NK 1; NK1; UDP GlcUA glycoprotein beta 1 3 glucuronyltransferase; UDP-GlcUA:glycoprotein beta-1.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken,
CD57,髓鞘相关糖蛋白CD57抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CD57
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD57,髓鞘相关糖蛋白CD57抗体PubMedPubMed
产品介绍background:
CD57 recognizes a (Mr 100-110kDa) oligosaccharide antigenic determinant on myeloid cells and on a variety of polypeptides, lipids and chondroitan sulfate proteoglycans. This surface antigen is associated with myelin-associated glycoprotein (MAG). The CD57 antigen is present on 15-20% of normal peripheral blood mononuclear cells. It is expressed on a subset of natural killer cells (60%) and on a subset of T-lymphocytes. This carbohydrate is also present on N-CAM in the nervous system.

Function:
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.

Subunit:
Homodimer (Potential).

Subcellular Location:
Golgi apparatus membrane; Single-pass type II membrane protein.

Tissue Specificity:
Mainly expressed in the brain.

Similarity:
Belongs to the glycosyltransferase 43 family.

Gene ID:
27087

CD57,髓鞘相关糖蛋白CD57抗体Database links:
Entrez Gene: 27087 Human
Omim: 151290 Human
SwissProt: Q9P2W7 Human
Unigene: 381050 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD57是一种分子量为110KD的糖蛋白,它是自然杀伤细胞(NK)和杀伤细胞的特异性表面抗原。CD57表达于15-20%的外周血单核细胞，60%的NK活化细胞以及T细胞亚群。该抗体可以标记NK细胞，也可识别非淋巴组织的一些细胞。可用于NK细胞介导的细胞毒、NK细胞及T细胞亚群的功能等方面的研究，也可标记神经内分泌细胞及其肿瘤。