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上海信裕生物科技有限公司
ARNT2抗体

ARNT2抗体

商家询价

产品名称： ARNT2抗体

英文名称： ARNT2Antibody

产品编号： XY12810-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 ARNT2抗体

Applications
In-house applications ELISA, WB, IHC     Application not tested? Please see our Guarantee.
Species specificity Human,Mouse,Rat; other species not tested.
Images
Prev1NextView more validation data
  • 12810-1-AP;HEK-293 cellHEK-293 cells were subjected to SDS PAGE followed by western blot with 12810-1-AP(ARNT2 antibody) at dilution of 1:300
  • 12810-1-AP;GliomasImmunohistochemical of paraffin-embedded human gliomas using 12810-1-AP(ARNT2 antibody) at dilution of 1:100 (under 10x lens)
Positive WB detected in HEK-293 cells, Jurkat cells, Raji cells
Positive IHC detected in Human gliomas tissue
Recommended dilution WB : 1:200-1:2000
IHC : 1:20-1:200
 ARNT2抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information ARNT2抗体
Immunogen ARNT2 fusion protein ag3536 Full name Aryl-hydrocarbon receptor nuclear translocator 2
Calculated molecular
weight		 716aa,79 kDa Observed molecular 
weight		 80-85kd
GenBank accession 
number		 BC036099 Gene ID (NCBI) 9915
Gene symbol ARNT2 Synonyms ARNT protein 2, ARNT2, bHLHe1, KIAA0307
Background

Aryl-hydrocarbon receptor nuclear translocator 2(ARNT2), is a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. It specifically recognizes the xenobiotic response element(XRE). ARNT2 plays an important role in normal glucose handling in pancreatic beta cell function in humans and mice. ARNT2 proteins are dimeric partners for other PAS proteins such as HIF and SIM. ARNT2 and the other ARNT family members, e.g., ARNT, hypoxin inducible factor 1α (HIF1α), HIF2α, and aryl hydrocarbon receptor (AhR), are thought to function as heterodimers, and regulate the expression, and thereby the function, of many genes. Under hypoxic conditions, it complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. Modulation of ARNT2 in pancreatic beta cells affects glucose stimulated insulin secretion (GSIS). This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human ARNT2. ARNT2抗体

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