SAMD9,SAMD9蛋白抗体

产品编号HZ-9002R
英文名称SAMD9
中文名称SAMD9蛋白抗体
别 名SAM domain-containing protein 9; SAMD9; SAMD9_HUMAN; sterile alpha motif domain containing 9; Sterile alpha motif domain-containing protein 9; C7orf5.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Sheep,
SAMD9,SAMD9蛋白抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量184kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SAMD9
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SAMD9,SAMD9蛋白抗体PubMedPubMed
产品介绍background:
Defects in SAMD9 are the cause of normophosphatemic familial tumoral calcinosis (NFTC). NFTC is an uncommon life-threatening disorder characterized by massive periarticular, and seldom visceral, deposition of calcified tumors.

Function:
May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2.

Subunit:
Interacts with RGL2.

Subcellular Location:
Cytoplasm

Tissue Specificity:
Widely expressed. Very low levels in skeletal muscle. Not detected in fetal brain. Down-regulated in aggressive fibromatosis, as well as in breast and colon cancers.

DISEASE:
Defects in SAMD9 are the cause of tumoral calcinosis, normophosphatemic, familial (NFTC) [MIM:610455]. An uncommon disorder characterized by progressive deposition of calcified masses in cutaneous and subcutaneous tissues. Serum phosphate levels are normal. Clinical features include painful calcified ulcerative lesions, massive calcium deposition in the mid- and lower dermis, severe skin and bone infections, erythematous papular skin eruption in infancy, conjunctivitis, and gingivitis. NFTC shows a striking resemblance to acquired dystrophic calcinosis, in which tissue calcification occurs as a consequence of tissue injury/inflammation.

Similarity:
Contains 1 SAM (sterile alpha motif) domain.

Database links:
Entrez Gene: 54809 Human
Omim: 610456 Human
SwissProt: Q5K651 Human
Unigene: 65641 Human

SAMD9,SAMD9蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.