FITC标记的羧基端小结构域磷酸酶2抗体
产品名称： FITC标记的羧基端小结构域磷酸酶2抗体
英文名称： Anti-CTDSP2/FITC
产品编号： HZ-14099R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CTDSP2/FITC Conjugated antibody
FITC标记的羧基端小结构域磷酸酶2抗体
| 英文名称 | Anti-CTDSP2/FITC |
| 中文名称 | FITC标记的羧基端小结构域磷酸酶2抗体 |
| 别 名 | Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 2; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; CTDS2_HUMAN; Ctdsp2; NIF2; NLI interacting factor 2; NLI-interacting factor 2; Nuclear LIM interactor interacting factor 2; Nuclear LIM interactor-interacting factor 2; OS4; Protein OS 4; Protein OS-4; PSR2; SCP2; Small C-terminal domain phosphatase 2; Small CTD phosphatase 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 染色质和核信号 信号转导 肿瘤细胞生物标志物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CTDSP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. Subunit: Monomer (By similarity). Interacts with REST. Subcellular Location: Nucleus (By similarity). Tissue Specificity: Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver. Similarity: Contains 1 FCP1 homology domain. Database links: Entrez Gene: 10106 Human Entrez Gene: 506115 Cow Entrez Gene: 52468 Mouse Omim: 608711 Human SwissProt: O14595 Human SwissProt: Q8BX07 Mouse Unigene: 524530 Human Unigene: 29490 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
优选地，在最大的RNA聚合酶II亚基POLR2A的C端结构域(CTD)中催化串联7个残基内的“Ser-5”的去磷酸化。可能通过控制从起始/封端到proc的转变，负调控RNA聚合酶II的转录。转录本的延伸。通过REST招募含有Re-1元素的神经元基因，导致非神经细胞中的神经元基因沉默。可能有助于肉瘤的发展。