Gemin 3,脊髓性肌萎缩症蛋白SMA抗体

产品编号HZ-11563R
英文名称Gemin 3
中文名称脊髓性肌萎缩症蛋白SMA抗体
别 名Gemin3; Component of gems 3; DDX 20; DDX20; DDX20_HUMAN; DEAD (Asp Glu Ala Asp) box polypeptide 20; DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein 20; DEAD box protein DP 103; DEAD box protein DP103; DEAD-box protein DP103; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 103kD; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20; DEAD/H BOX 20; DKFZP434H052; DP 103; DP103; Gemin-3; Gemin3; Probable ATP dependent RNA helicase DDX20; Probable ATP-dependent RNA helicase DDX20; SMN interacting protein.
说 明 书0.1ml 0.2ml
研究领域肿瘤 神经生物学 信号转导 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog,
Gemin 3,脊髓性肌萎缩症蛋白SMA抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量92kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Gemin 3 (101-200aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Gemin 3,脊髓性肌萎缩症蛋白SMA抗体PubMedPubMed
产品介绍background:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008].

Function:
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs.

Subunit:
Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with SMN1 and with several spliceosomal snRNP core Sm proteins, including SNUPN, SNRPB, SNRPD2 and SNRPD3. Interacts with PPP4R2. Interacts with EBV EBNA2 and EBNA3C. Interacts with FOXL2. [SUBCELLULAR LOCATION] Cytoplasm. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems).

Subcellular Location:
Cytoplasm. Nucleus

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the DEAD box helicase family. DDX20 subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.

Gemin 3,脊髓性肌萎缩症蛋白SMA抗体Database links:
Entrez Gene: 11218 Human
Entrez Gene: 53975 Mouse
Omim: 606168 Human
SwissProt: Q9UHI6 Human
SwissProt: Q9JJY4 Mouse
Unigene: 591405 Human
Unigene: 272826 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.