ALPHA E CATENIN抗体
Applications
| In-house applications |
ELISA, WB, IHC, IF, FC, IP Application not tested? Please see our Guarantee. |
| Published applications |
WB |
Publications |
2 citations –view here |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
| Published Species |
Human |
|
Images
Prev12Next
 Immunohistochemistry of paraffin-embedded human stomach tissue slide using 12831-1-AP( CTNNA1 Antibody) at dilution of 1:50 (under 40x lens) Immunofluorescent analysis of A431 cells using 12831-1-AP( CTNNA1 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG 1X10^6 MCF-7 cells were stained with 0.2ug CTNNA1 antibody (12831-1-AP, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000. mouse uterus tissue were subjected to SDS PAGE followed by western blot with 12831-1-AP( CTNNA1 Antibody) at dilution of 1:2000 IP Result of anti-CTNNA1 (IP:12831-1-AP, 4ug; Detection:12831-1-AP 1:700) with mouse brain tissue lysate 4000ug. Immunohistochemistry of paraffin-embedded human stomach tissue slide using 12831-1-AP( CTNNA1 Antibody) at dilution of 1:50 (under 10x lens)
|
| Positive WB detected in |
Mouse uterus tissue |
| Positive IP detected in |
Mouse brain tissue |
| Positive IHC detected in |
Human stomach tissue, human colon tissue, human pancreas cancer tissue |
| Positive IF detected in |
A431 cells |
| Positive FC detected in |
MCF-7 cells |
| Recommended dilution |
WB : 1:1000-1:10000
IP : 1:200-1:2000
IHC : 1:20-1:200
IF : 1:10-1:100 |
ALPHA E CATENIN抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen |
Alpha E catenin fusion protein ag3565 |
Full name |
Catenin (cadherin-associated protein), alpha 1, 102kDa |
Calculated molecular
weight |
906aa,100 kDa |
Observed molecular
weight |
100 kDa |
GenBank accession
number |
BC031262 |
Gene ID (NCBI) |
1495 |
| Gene symbol |
CTNNA1 |
Synonyms |
Alpha catenin, Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1, α-catenin, α-E-catenin, αE-catenin |
Background ALPHA E CATENIN抗体
|
Alpha catenin is an essential component of adherens junctions that connects E-cadherin-β-catenin complexes with the actin cytoskeleton. It also recruits a range of other important proteins to developing intercellular junctions. Three alpha catenins exist in human: alpha-E-catenin, alpha-N-catenin, and alpha-T-catenin, which share substantial amino-acid sequence similarity but have distinct tissue distribution. alpha-E-catenin is ubiquitously expressed, alpha-N-catenin is restricted to neuronal tissue, and alpha-T-catenin is primarily expressed in heart tissue. Reduced levels of alpha-E-catenin protein seem to be characteristic of many different human cancers, including malignant tumours of the breast, colon, stomach, oesophagus, bladder and liver. In addition, the loss of alpha-E-catenin often correlates with the degree of tumour differentiation and metastasis. ALPHA E CATENIN抗体
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