FITC标记的G蛋白信号转导调节因子1抗体
产品名称： FITC标记的G蛋白信号转导调节因子1抗体
英文名称： Anti-RGS1/FITC
产品编号： HZ-19851R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RGS1/FITC Conjugated antibody
FITC标记的G蛋白信号转导调节因子1抗体
| 英文名称 | Anti-RGS1/FITC |
| 中文名称 | FITC标记的G蛋白信号转导调节因子1抗体 |
| 别 名 | 1R20; B cell activation protein BL34; B-cell activation protein BL34; BL34; Early response protein 1R20; IER 1; IER1; Immediate early response 1 B cell specific; immediate-early response 1, B-cell specific; IR20; Regulator of G protein signalling 1; Regulator of G-protein signaling 1; RGS 1; RGS1; RGS1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 淋巴细胞 b-淋巴细胞 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RGS1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. Tissue Specificity: B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high. Post-translational modifications: Could be phosphorylated. Might be functionally regulated by protein kinase(s). Similarity: Contains 1 RGS domain. Database links: Entrez Gene: 100034151 Horse Entrez Gene: 5996 Human Entrez Gene: 50778 Mouse Entrez Gene: 54289 Rat Omim: 600323 Human SwissProt: Q6RG78 Horse SwissProt: Q08116 Human SwissProt: Q9JL25 Mouse SwissProt: P97844 Rat Unigene: 75256 Human Unigene: 103701 Mouse Unigene: 14787 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码G蛋白信号家族的调节成员。这种蛋白质位于质膜的胞质侧，含有一个保守的120个氨基酸基序，称为RGS结构域。该蛋白通过与活化的GTP结合的Gα亚基结合并充当GTP酶激活蛋白(GAP)来减弱G蛋白的信号转导活性，从而提高GTP向GDP的转化率。这种水解允许Gα亚基结合Gβ/γ亚基异二聚体，形成非活性的G蛋白异三聚体，从而终止信号。[ RefSeq，JUL 2008 ]