FITC标记的睾丸特异丝氨酸/苏氨酸激酶6抗体
产品名称： FITC标记的睾丸特异丝氨酸/苏氨酸激酶6抗体
英文名称： Anti-TSSK6/FITC
产品编号： HZ-9734R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TSSK6/FITC Conjugated antibody
FITC标记的睾丸特异丝氨酸/苏氨酸激酶6抗体
| 产品编号 | bs-9734R-FITC |
| 英文名称 | Anti-TSSK6/FITC |
| 中文名称 | FITC标记的睾丸特异丝氨酸/苏氨酸激酶6抗体 |
| 别 名 | Cancer/testis antigen 72; CT72; EC 2.7.11.1; Serine/threonine-protein kinase SSTK; Small serine/threonine kinase; Small serine/threonine protein kinase; SSTK; testis-specific serine kinase 6; Testis-specific serine/threonine kinase 6; Testis-specific serine/threonine-protein kinase 6; TSK 6; TSSK4; TSSK6_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 发育生物学 信号转导 细胞周期蛋白 细胞分化 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TSSK6/CT72 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility. Function: Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). Subunit: Interacts with the heatshock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity. Tissue Specificity: Highly expressed in testis. Expressed at lower levels in colon, small intestine, ovary, prostate, thymus, spleen and peripheral blood leukocytes. Post-translational modifications: Autophosphorylated. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 1 protein kinase domain. Database links: Entrez Gene: 83983 Human Entrez Gene: 83984 Mouse Omim: 610712 Human SwissProt: Q9BXA6 Human SwissProt: Q925K9 Mouse Unigene: 532711 Human Unigene: 432504 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
蛋白在丝氨酸和苏氨酸残基上的磷酸化和去磷酸化是调节真核细胞中广泛的细胞功能的重要手段，包括细胞分裂、稳态和凋亡。一组紧密参与这一过程的蛋白质是丝氨酸/苏氨酸（SE/THR）蛋白激酶。TSK 6（睾丸特异丝氨酸激酶6），又称SSTK、TSK4、FKSG822或CT72，是含有一个蛋白激酶结构域的273氨基酸蛋白，属于SR/THR蛋白激酶家族。在卵巢、结肠、胸腺、小肠和脾脏中低表达的睾丸中高表达，TSK 6催化参与精子生产和染色质重塑的蛋白质的ATP依赖性磷酸化。TSK 6使用镁作为辅助因子，被认为是需要适当的精子发育和功能，以及DNA凝聚事件。TSK 6基因的缺陷与男性不育有关，其特征是精子数量低，精子活力下降。