Phospholipase C beta 3,磷酯酶Cβ3抗体

产品编号HZ-4702R
英文名称Phospholipase C beta 3
中文名称磷酯酶Cβ3
别 名PLCB3; PLC beta3; 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase beta 3; 1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase beta-3; Phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-3; Phospholipase C beta 3; Phospholipase C beta 3 (phosphatidylinositol specific); Phospholipase C-beta-3; PLC beta 3; PLC-beta-3; Plcb3; PLCB3_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 信号转导 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea Pig,
Phospholipase C beta 3,磷酯酶Cβ3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量136kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PLC beta3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Phospholipase C beta 3,磷酯酶Cβ3抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Function:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Subunit:
Interacts with SHANK2. Interacts with LPAR2.

Subcellular Location:
Membrane; Peripheral membrane protein.

Similarity:
Contains 1 C2 domain.
Contains 1 PI-PLC X-box domain.
Contains 1 PI-PLC Y-box domain.

Phospholipase C beta 3,磷酯酶Cβ3抗体Database links:
Entrez Gene: 5331 Human
Entrez Gene: 18797 Mouse
Entrez Gene: 29322 Rat
Omim: 600230 Human
SwissProt: Q01970 Human
SwissProt: P51432 Mouse
SwissProt: Q99JE6 Rat
Unigene: 523761 Human
Unigene: 591953 Human
Unigene: 273204 Mouse
Unigene: 16983 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.